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Target Organs and Levels of Evidence for TR-288

Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,3-Butadiene
106-99-0
10/28/1983Chemical intermediate. Manufacture of synthetic rubber and of thermoplastic resins. Produced from petroleum gases (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,625,1250 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LYMPHOMA 0/50 23/50 29/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49
  • Forestomach: PAPILLOMA 0/49 5/40 0/44
  • Vascular System (Heart): HEMANGIOSARCOMA 0/50 16/49 7/49
May Have Been Related
  • Zymbal Gland: CARCINOMA 0/50 0/50 2/50
  • Preputial Gland: SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50
  • Brain: GLIOMA 0/50 2/48 1/49
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC; FIBROSIS; METAPLASIA, CARTILAGINOUS; METAPLASIA, OSSEOUS
  • TESTES: ATROPHY
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LYMPHOMA 1/50 10/49 10/49
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49
  • Forestomach: PAPILLOMA 0/49 4/42 10/49
  • Liver: ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49
  • Mammary Gland: ACINAR CELL CARCINOMA 0/50 2/49 6/49
  • Ovary: GRANULOSA CELL TUMOR 0/49 6/45 12/48
  • Vascular System (Heart): HEMANGIOSARCOMA 0/50 11/48 18/49
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC; FIBROSIS; METAPLASIA, CARTILAGINOUS; METAPLASIA, OSSEOUS
  • OVARY: ATROPHY