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https://ntp.niehs.nih.gov/go/8161

Target Organs and Levels of Evidence for TR-289

Toxicology and Carcinogenesis Studies of Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Benzene
71-43-2
07/27/1984In manufacture of medicinal chemicals, dyes, organic compounds, artificial leather, linoleum, oil cloth, varnishes, lacquers, solvent for waxes, resins, oils. Used to destroy screwworm larvae in wounds; veterinary use (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
FR&M: 0,25,50,100, MR: 0,50,100,200 MG/KG/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: CARCINOMA 2/32 6/46 10/42
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50
  • Skin: SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: CARCINOMA 0/45 5/40 5/44 14/46
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39
  • Hematopoietic System: LYMPHOMA 4/49 10/48 10/50 15/49
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49
  • Harderian Gland: ADENOMA 0/49 9/46 13/49 11/48
  • Preputial Gland: SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31
  • Hematopoietic System: LYMPHOMA 15/49 25/45 26/50 22/49
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49
  • Ovary: BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48
  • Mammary Gland: CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49