National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9630

Target Organs and Levels of Evidence for TR-295

Toxicology and Carcinogenesis Studies of Chrysotile Asbestos (CASRN 12001-29-5) in F344/N Rats (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Asbestos, chrysotile(IR)
12001-29-5
07/27/1984Asbestos, chrysotile: asbestos cement. Textiles. Insulation. Friction products. Fireproofing agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,1 %/250 PER GROUP
National Institute of Env. Health Sciences

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: ADENOMATOUS POLYP 0/85 9/250 2/100
Female Rats: No Evidence


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Asbestos, chrysotile(IR)
12001-29-5
07/27/1984Asbestos, chrysotile: asbestos cement. Textiles. Insulation. Friction products. Fireproofing agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,1% /250 PER GROUP
Hazleton, Vienna

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Asbestos, chrysotile(IR) + Dimethyl hydrazine
12001-29-5
07/27/1984Asbestos, chrysotile: asbestos cement. Textiles. Insulation. Friction products. Fireproofing agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,1 %/175 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Inadequate Study
Female Rats: Inadequate Study


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Asbestos, chrysotile(SR)
12001-29-5
07/27/1984Asbestos, chrysotile: asbestos cement. Textiles. Insulation. Friction products. Fireproofing agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,1 %/250 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.