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Target Organs and Levels of Evidence for TR-298

Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate (CASRN 597-25-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Dimethyl morpholinophosphoramidate
597-25-1
11/02/1984Stimulant for nerve agents in chemical defense training; not produced commercially in U.S.Gavage
R: 0,150,300,600, FM: 0,300,600, MM: 0,150,300 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 14/50 21/50 19/50 25/50
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 9/50 13/50 12/49 18/50
Male Mice: No Evidence
Female Mice: No Evidence