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Target Organs and Levels of Evidence for TR-301

Toxicology and Carcinogenesis Studies of ORTHO-Phenylphenol (CASRN 90-43-7) Alone and with 7,12-Dimethylbenz(a)anthracene (CASRN 57-97-6) in Swiss CD-1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
o-Phenylphenol
90-43-7
03/29/1985Fungicide. Germicide. Household disinfectant. Preservative in water-oil emulsions. Dish-washing formulations, rubber industry. Produced from coal tars. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Topical Application
55.5 MG/0.1 ML/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ULCERATION; INFLAMMATION; HYPERKERATOSIS
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ULCERATION; INFLAMMATION; HYPERKERATOSIS