National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9558

Target Organs and Levels of Evidence for TR-304

Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chlorendic acid
115-28-6
08/14/1985Flame retardant, intermediate for plasticizers, hardening agent (HSDB 1990)Dosed-Feed
0,620,1250 PPM/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 2/50 21/50 23/50
  • Pancreas Acinar Cell: ADENOMA 0/49 4/50 6/50
May Have Been Related
  • Lung: ADENOMA 0/50 3/50 5/50
  • Preputial Gland: CARCINOMA 1/50 8/50 4/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 1/50 3/49 11/50; CARCINOMA 0/50 3/49 5/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 5/50 9/49 10/50; CARCINOMA 9/50 17/49 20/50
Female Mice: No Evidence


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.