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Target Organs and Levels of Evidence for TR-305

Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chlorinated paraffins: C23, 43% chlorine
08/14/1985Additive in extreme pressure lubricant; flame retardant in rubber, plastic, and paintGavage
FR: 0,100,300,900, MR: 0,1875,3750, M: 0,2500,5000 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 1/50 4/50 6/50 7/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LYMPHOMA 6/50 12/50 16/50
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 3/50 2/49 7/50 OR CARCINOMA 1/50 1/49 6/50 COMBINED 4/50 3/49 10/50