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Target Organs and Levels of Evidence for TR-306

Toxicology and Carcinogenesis Studies of Dichloromethane (Methylene Chloride) (CASRN 75-09-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methylene chloride
75-09-2
03/29/1985Solvent in paint removers, degreasers, aerosol propellants, extraction solvent in food processing; pharmaceutical aid, component of fire extinguishing compound (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R: 0,1000,2000,4000, M: 0,2000,4000 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 0/50 0/50 2/50 4/50 COMBINED 0/50 0/50 2/50 5/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 5/50 11/50 13/50 22/50 COMBINED 5/50 11/50 13/50 23/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 10/50 14/49 14/49 OR CARCINOMA 13/50 15/49 26/49 COMBINED 22/50 24/49 33/49
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 19/50 24/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 10/50 28/50
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 2/50 6/48 22/48 OR CARCINOMA 1/50 11/48 32/48 COMBINED 3/50 16/48 40/48
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 23/48 28/48; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 13/48 29/48