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Target Organs and Levels of Evidence for TR-309

Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Decabromodiphenyl oxide
1163-19-5		08/14/1985Flame retardant. For nitrile resins, polyester and textile coatings.Dosed-Feed
0,25000,50000 PPM/50 PER GROUP		Hazleton, Vienna

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 1/50 7/50 15/49
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 1/50 3/49 9/50
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 12/50 12/50 OR CARCINOMA 5/50 14/50 8/50 COMBINED 8/50 22/50 18/50
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 3/50 3/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 0/50 4/50 3/50
Non-Neoplastic Lesions
  • THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
Female Mice: No Evidence