Target Organs and Levels of Evidence for TR-309
Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
|---|
Decabromodiphenyl oxide
1163-19-5 | 08/14/1985 | Flame retardant. For nitrile resins, polyester and textile coatings. | Dosed-Feed
0,25000,50000 PPM/50 PER GROUP | Hazleton, Vienna |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 1/50 7/50 15/49
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 1/50 3/49 9/50
|
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 4/50 12/50 12/50 OR CARCINOMA 5/50 14/50 8/50 COMBINED 8/50 22/50 18/50
- Thyroid Gland Follicular Cell:
ADENOMA 0/50 3/50 3/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 0/50 4/50 3/50
|
| Non-Neoplastic Lesions | - THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
|
Female Mice: No Evidence
