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Target Organs and Levels of Evidence for TR-316

Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN 513-37-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Dimethylvinyl chloride (DMVC)
513-37-1
12/09/1985Chemical intermediate used in organic synthesis (Merck 1989)Gavage
0,100,200 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOCARCINOMA 0/47 8/46 4/32; CARCINOMA 0/47 12/46 24/32; SQUAMOUS CELL CARCINOMA 0/47 3/46 0/32
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 2/50 COMBINED 0/50 5/50 4/50
  • Esophagus: SQUAMOUS CELL PAPILLOMA 0/50 2/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/50 4/50 1/49 COMBINED 0/50 6/50 4/49
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/49 7/50 0/50; SQUAMOUS CELL CARCINOMA 0/49 7/50 0/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOCARCINOMA 0/50 3/49 6/41; CARCINOMA 0/50 11/49 28/41; SQUAMOUS CELL CARCINOMA 0/50 2/49 2/41
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/50 COMBINED 0/50 2/50 5/50
  • Esophagus: SQUAMOUS CELL CARCINOMA 0/49 3/50 1/49
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 4/50 1/49 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 1/49 COMBINED 1/50 9/50 2/49
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/48 3/47 8/44; SQUAMOUS CELL CARCINOMA 0/48 42/47 35/44
  • Preputial Gland: SQUAMOUS CELL CARCINOMA 1/48 3/47 16/44
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL CARCINOMA 0/50 40/47 36/43