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Target Organs and Levels of Evidence for TR-318

Toxicology and Carcinogenesis Studies of Ampicillin Trihydrate (CASRN 7177-48-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Ampicillin trihydrate
7177-48-2
12/09/1985Antibiotic, antimicrobialGavage
R: 0,750,1500, M: 0,1500,3000 MG/KG/50 PER GROUP
Springborn Inst. for Bioresearch, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 13/50 12/50 23/49 OR MALIGNANT PHEOCHROMOCYTOMA 1/50 5/50 1/49 COMBINED 13/50 16/50 23/49
  • Hematopoietic System: LEUKEMIA 5/50 14/50 13/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERKERATOSIS; ACANTHOSIS
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: ULCERS; INFLAMMATION; HYPERKERATOSIS; ACANTHOSIS
Female Mice: No Evidence