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Target Organs and Levels of Evidence for TR-320

Toxicology and Carcinogenesis Studies of Rotenone (CASRN 83-79-4) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
08/19/1986Fish poison, medical antiprotozoal, insecticide on fruits, livestock, vegetables, forage crops, occurs naturally in certain roots (Merck 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0, 38, OR 75 PPM M: 0, 600, OR 1200 PPM; 50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Parathyroid Gland: ADENOMA 1/41 0/44 4/44
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: No Evidence