National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13048

Target Organs and Levels of Evidence for TR-322

Toxicology and Carcinogenesis Studies of Phenylephrine Hydrochloride (CASRN 61-76-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Phenylephrine hydrochloride
61-76-7
03/26/1986Sympathomimetic amine, nasal decongestant, mydriaticDosed-Feed
R: 0,620,1250 M: 0,1250,2500 PPM/50 PER GROUP
Physiological Research Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: INFLAMMATION, CHRONIC FOCAL
  • PROSTATE GLAND: INFLAMMATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: INFLAMMATION, CHRONIC FOCAL
Male Mice: No Evidence
Female Mice: No Evidence


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