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Target Organs and Levels of Evidence for TR-326

Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Ethylene oxide
75-21-8		08/19/1986Accelerates ripening in fruit and maturing of tobacco leaves. Fungistat. Rocket propellant. Fumigant for foodstuffs and textiles. Organic synthesis. Sterilize surgical instruments. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,50,100 PPM/50 PER GROUP		Battelle Northwest Laboratory

Levels of Evidence

Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50
  • Harderian Gland: CYSTADENOMA 1/43 9/44 8/42
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49
  • Harderian Gland: CYSTADENOMA 1/46 6/46 8/47
  • Uterus/Cervix: ADENOCARCINOMA 0/49 1/47 5/49
  • Mammary Gland: ADENOCARCINOMA 1/49 6/48 4/49; ADENOSQUAMOUS CARCINOMA 0/49 2/48 2/49
  • Hematopoietic System: LYMPHOMA 9/49 6/48 22/49