https://ntp.niehs.nih.gov/go/13728
Target Organs and Levels of Evidence for TR-326
Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
|---|
Ethylene oxide
75-21-8 | 08/19/1986 | Accelerates ripening in fruit and maturing of tobacco leaves. Fungistat. Rocket propellant. Fumigant for foodstuffs and textiles. Organic synthesis. Sterilize surgical instruments. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. | Inhalation
0,50,100 PPM/50 PER GROUP | Battelle Northwest Laboratory |
Levels of Evidence
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50
- Harderian Gland:
CYSTADENOMA 1/43 9/44 8/42
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49
- Harderian Gland:
CYSTADENOMA 1/46 6/46 8/47
- Uterus/Cervix:
ADENOCARCINOMA 0/49 1/47 5/49
- Mammary Gland:
ADENOCARCINOMA 1/49 6/48 4/49; ADENOSQUAMOUS CARCINOMA 0/49 2/48 2/49
- Hematopoietic System:
LYMPHOMA 9/49 6/48 22/49
|
