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Target Organs and Levels of Evidence for TR-328

Toxicology and Carcinogenesis Studies of Methyl Carbamate (CASRN 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methyl carbamate
598-55-0
08/19/1986Chemical intermediate for fabric finish resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,100,200, M: 0,500,1000 MG/KG/50 PER GROUP
BioReliance, Inc

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 3/50 0/50 3/49; CARCINOMA 1/50 0/50 4/49
Non-Neoplastic Lesions
  • HARDERIAN GLAND: INFLAMMATION 4/50 11/50 16/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 0/50 0/50 5/49; CARCINOMA 0/50 0/50 1/50
Non-Neoplastic Lesions
  • HARDERIAN GLAND: INFLAMMATION 7/50 16/50 30/50
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: HYPERPLASIA, ADENOMATOUS 13/50 19/50 24/49; HISTIOCYTOSIS 11/50 7/50 21/49
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: HYPERPLASIA, ADENOMATOUS 7/49 10/50 18/50; HISTIOCYTOSIS 9/49 10/50 21/50