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Target Organs and Levels of Evidence for TR-329

Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Epoxybutane
106-88-7
08/19/1986For production of butanediols, glycol esters & ethers, preparation of surfactants & gasoline additives, intermediate For polymers, stabilizer (HSDB 1990).Inhalation
R: 0,200,400, M: 0,50,100 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 7/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/50 1/49 OR ALVEOLAR/BRONCHIOLR CARCINOMA 0/50 1/50 4/49 COMBINED 0/50 2/50 5/49
Non-Neoplastic Lesions
  • NASAL CAVITY: HYPERPLASIA, ADENOMATOUS; INFLAMMATION, NOS; INFLAMMATION, SEROUS, INFLAMMATION, SUPPURATIVE
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 2/50
Non-Neoplastic Lesions
  • NASAL CAVITY: HYPERPLASIA, ADENOMATOUS; INFLAMMATION, NOS; INFLAMMATION, SEROUS; INFLAMMATION, SUPPURATIVE
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC