https://ntp.niehs.nih.gov/go/13734

Target Organs and Levels of Evidence for TR-329

Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
1,2-Epoxybutane
106-88-7		 08/19/1986 Inhalation
R: 0,200,400, M: 0,50,100 PPM/50 PER GROUP		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 7/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/50 1/49 OR ALVEOLAR/BRONCHIOLR CARCINOMA 0/50 1/50 4/49 COMBINED 0/50 2/50 5/49
Non-Neoplastic Lesions
  • NASAL CAVITY: HYPERPLASIA, ADENOMATOUS; INFLAMMATION, NOS; INFLAMMATION, SEROUS, INFLAMMATION, SUPPURATIVE
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 2/50
Non-Neoplastic Lesions
  • NASAL CAVITY: HYPERPLASIA, ADENOMATOUS; INFLAMMATION, NOS; INFLAMMATION, SEROUS; INFLAMMATION, SUPPURATIVE
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC