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https://ntp.niehs.nih.gov/go/13738

Target Organs and Levels of Evidence for TR-331

Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CASRN 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Malonaldehyde, sodium salt
24382-04-5
03/04/1987Indicator of food freshness; no commercial useGavage
R: 0,50,100, M: 0,60,120 MG/KG/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50
May Have Been Related
  • Pancreas Islet Cell: ADENOMA 0/49 9/50 1/49
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: ULCERS; INFLAMMATION
  • FORESTOMACH: HYPERPLASIA, EPITHELIAL
  • EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACT, CRYSTALLINE LENS
  • LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: ULCERS; INFLAMMATION
  • FORESTOMACH: HYPERPLASIA, EPITHELIAL
  • EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACTS, CRYSTALLINE LENS
  • LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • PANCREATIC ACINUS: ATROPHY
  • HAIR SHAFTS: PIGMENTATION LOSS
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • PANCREATIC ACINUS: ATROPHY
  • HAIR SHAFTS: PIGMENTATION LOSS