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Target Organs and Levels of Evidence for TR-332

Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2-Mercaptobenzothiazole
149-30-4
03/04/1987Rubber vulcanization accelerator. Salts used as fungicide. Corrosion inhibitor for copper in aqueous systems, cutting oils and petroleum products. Additive in extreme-pressure greases. Gavage
FR: 0,188,375, MR&M: 0,375,750 MG/KG/50 PER GROUP
Physiological Research Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 7/50 16/50 3/50
  • Pancreas Acinar Cell: ADENOMA 2/50 13/50 6/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 18/50 25/50 22/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 COMBINED 18/50 27/50 24/49
  • Preputial Gland: ADENOMA 0/50 4/50 4/50 OR CARCINOMA 1/50 2/50 1/50 COMBINED 1/50 6/50 5/50
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 1/50 5/50 6/50
  • Pituitary Gland: ADENOMA 15/49 24/50 25/50
Male Mice: No Evidence
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 3/50 7/49 4/50 OR CARCINOMA 1/50 5/49 0/50 COMBINED 4/50 12/49 4/50