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Target Organs and Levels of Evidence for TR-333

Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
N-Phenyl-2-naphthylamine
135-88-6
03/04/1987Rubber antioxidant. Lubricant. Catalyst. In dyes, surgical plasters. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,2500,5000 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE; MINERALIZATION; NECROSIS; CALCULI; HYPERPLASIA; HYDRONEPHROSIS; ATROPHY; FIBROSIS
Male Mice: No Evidence
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 1/47 OR ADENOCARCINOMA 0/50 0/50 1/50
Non-Neoplastic Lesions
  • KIDNEY: KARYOMEGALY; NEPHROPATHY