National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13748

Target Organs and Levels of Evidence for TR-336

Toxicology and Carcinogenesis Studies of Penicillin VK (CASRN 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Penicillin VK
132-98-9
07/14/1987AntibioticGavage
0,500,1000 MG/KG/ 50 PER GROUP
Springborn Inst. for Bioresearch, Inc.

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: CYST 0/46 8/47 20/46; INFLAMMATION, CHRONIC FOCAL 1/46 11/47 21/46; FIBROSIS 0/46 1/47 13/46; HYPERPLASIA, EPITHELIAL 1/46 26/47 34/46; METAPLASIA, SQUAMOUS 0/46 1/47 7/46
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: CYST 0/44 5/45 15/47; INFLAMMATION CHRONIC FOCAL 0/44 10/45 30/47; FIBROSIS 0/44 2/45 11/47; HYPERPLASIA, EPITHELIAL 0/44 19/45 38/47; METAPLASIA, SQUAMOUS 0/44 1/45 5/47


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