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Target Organs and Levels of Evidence for TR-342

Toxicology and Carcinogenesis Studies of Dichlorvos (CASRN 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Dichlorvos
62-73-7
07/14/1987Insecticide. Fumigant. Veterinary use for quick knockdown of insects. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Gavage
R: 0,4,8, MM: 0,10,20, FM: 0,20,40 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 25/50 30/49 33/50
  • Hematopoietic System: LEUKEMIA 11/50 20/50 21/50
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 2/50 3/47 6/50
  • Mammary Gland: FIBROADENOMA 9/50 19/50 16/50 OR ADENOMA 0/50 0/50 1/50 COMBINED 9/50 19/50 17/50
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 1/50 5/50
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 5/49 6/49 18/50