National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13765

Target Organs and Levels of Evidence for TR-345

Toxicology and Carcinogenesis Studies of Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Roxarsone
121-19-7
11/06/1987Antiprotozoan agent (growth promoter) and antibacterial agent in poultry. Reagent for zirconium. Dosed-Feed
R: 0,50,100 M: 0,100,200 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 1/50 1/50 5/50
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: No Evidence


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