https://ntp.niehs.nih.gov/go/13769

Target Organs and Levels of Evidence for TR-347

Toxicology and Carcinogenesis Studies of d-Limonene (CASRN 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
D-Limonene
5989-27-5		 04/18/1988 Gavage
FR: 0,300,600, MR: 0,75,150, FM: 0,500,1000, MM: 0,250,500 MG/KG/50 PER GROUP		 BioReliance, Inc

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 4/50 8/50 OR ADENOCARCINOMA 0/50 4/50 3/50
Non-Neoplastic Lesions
  • KIDNEY: PAPILLA, MINERALIZATION 7/50 43/50 48/50; HYPERPLASIA, TUBULAR CELL 0/50 4/50 7/50; HYPERPLASIA, EPITHELIAL 0/50 35/50 43/50; INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: No Evidence