National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13771

Target Organs and Levels of Evidence for TR-348

Toxicology and Carcinogenesis Studies of alpha-Methyldopa Sesquihydrate (CASRN 41372-08-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methyldopa sesquihydrate
41372-08-1
11/06/1987Antihypertensive agentDosed-Feed
R: 0, 3100, 6300, M: 0, 6300, 12500 PPM/50 PER GROUP
Physiological Research Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 2/50 0/50 OR ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 2/50 1/50
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CYSTS 2/50 10/50 10/50; NEPHROPATHY 3/50 21/50 32/50; KARYOMEGALY 0/50 46/50 44/50


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