National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13773

Target Organs and Levels of Evidence for TR-349

Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CASRN 87-86-5) in B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pentachlorophenol, Dowicide EC-7
87-86-5
04/18/1988Wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990).Dosed-Feed
M: 0, 100, 200, 600 PPM
Battelle Columbus Laboratory

Levels of Evidence

Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 5/35 13/48 17/48 32/49 OR CARCINOMA 1/35 7/48 7/48 9/49 COMBINED 6/35 19/48 21/48 34/49
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 0/34 4/48 21/48 44/49 OR MALIGNANT PHEOCHROMOCYTOMA 1/34 0/48 0/48 3/49 COMBINED 1/34 4/48 21/48 45/49
Non-Neoplastic Lesions
  • LIVER: CLEAR CELL FOCUS 0/35 19/48 21/48 19/49; INFLAMMATION, CHRONIC, ACTIVE 0/35 36/48 44/48 43/49; PIGMENTATION 0/35 40/48 37/48 45/49; BILE DUCT, HYPERPLASIA 1/35 3/48 5/48 32/49; HEPATOCYTE, CYTOMEGALY 0/35 48/48 48/48 47/49; HEPATOCYTE, NECROSIS, ACUTE 1/35 47/48 47/48 46/49
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Liver): HEMANGIOSARCOMA 0/34 1/50 1/49 8/48
  • Liver: ADENOMA 1/34 3/50 6/49 30/48 OR CARCINOMA 0/34 1/50 0/49 1/48 COMBINED 1/34 4/50 6/49 31/48
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 0/35 2/49 2/46 38/49
  • Vascular System (Spleen): HEMANGIOSARCOMA 0/34 0/50 2/50 2/47
Non-Neoplastic Lesions
  • LIVER: CLEAR CELL FOCUS 1/34 2/50 13/49 26/48; INFLAMMATION, CHRONIC, ACTIVE 0/34 4/50 30/49 47/48; PIGMENTATION 0/34 4/50 32/49 48/48; BILE DUCT, HYPERPLASIA 0/34 0/50 1/49 40/48; HEPATOCYTE, CYTOMEGALY 0/34 38/50 49/49 47/48; HEPATOCYTE, NECROSIS, ACUTE 2/34 25/50 49/49 48/48


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pentachlorophenol, DP-2
87-86-5
Wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
Battelle Columbus Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pentachlorophenol, purified
87-86-5
Wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
Battelle Columbus Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pentachlorophenol, technical
87-86-5
04/18/1988Wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
M: 0, 100, 200 PPM
Battelle Columbus Laboratory

Levels of Evidence

Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 5/32 20/47 33/48 OR CARCINOMA 2/32 10/47 12/48 COMBINED 7/32 26/47 37/48
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 0/31 10/45 23/45
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Liver): HEMANGIOSARCOMA 0/33 2/49 4/50
  • Liver: ADENOMA 3/33 8/49 8/50 OR CARCINOMA 0/33 1/49 1/50 COMBINED 3/33 9/49 9/50
  • Vascular System (Spleen): HEMANGIOSARCOMA 0/33 1/50 3/47


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