National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13779

Target Organs and Levels of Evidence for TR-352

Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats and B6C3F1 Mice

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
N-Methylolacrylamide
924-42-5
10/03/1988Proposed for use in sunscreen preparations. Polymers for coating, varnishes, adhesives, crease-proof and wrinkle-resistant fabrics, permanent-press textiles by irradiation bonding. Gavage
R: 0,6,12, M: 0,25,50 MG/KG/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: ADENOMA 1/48 14/49 29/50
  • Liver: ADENOMA 8/50 4/50 19/50 OR CARCINOMA 6/50 13/50 12/50 COMBINED 12/50 17/50 26/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 6/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/49 4/50 10/50 COMBINED 5/49 10/50 18/50
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: ADENOMA 5/47 8/45 20/48
  • Liver: ADENOMA 3/50 4/50 17/49
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 4/50 7/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 5/50 7/49 COMBINED 6/50 8/50 13/49
  • Ovary: GRANULOSA CELL TUMOR 0/50 5/45 5/47
Non-Neoplastic Lesions
  • OVARY: ATROPHY 3/50 39/45 38/47


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