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https://ntp.niehs.nih.gov/go/13783

Dimethoxane: Target Organs and Levels of Evidence for TR-354

Toxicology and Carcinogenesis Studies of Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Dimethoxane
828-00-2
10/03/1988Preservative for cutting oils, resin emulsions, cosmetics, inks, and water-based paints. Antimicrobial agent in adhesives and textile chemicals. Gasoline additive.Gavage
MR: 0,62.5,125, FR: 0,125,250, M: 0,250,500 MG/KG/60 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: ACANTHOSIS 5/50 9/50 23/50; HYPERKERATOSIS 1/50 0/50 10/50
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: ACANTHOSIS 0/50 8/50 44/50; HYPERKERATOSIS 0/50 5/50 22/50
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 2/47 3/47 7/50 OR SQUAMOUS CELL CARCINOMA 0/47 0/47 1/50 COMBINED 2/47 3/47 8/50
Non-Neoplastic Lesions
  • FORESTOMACH: ACANTHOSIS 2/47 4/47 20/50; HYPERKERATOSIS 1/47 1/47 23/50; HYPERPLASIA 2/47 7/47 11/50; INFLAMMATION, CHRONIC 0/47 0/47 5/50
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: ACANTHOSIS 0/49 5/48 23/48; HYPERKERATOSIS 0/49 4/48 27/48; HYPERPLASIA 3/49 14/48 22/48; INFLAMMATION, CHRONIC 0/49 0/48 1/48