Share This:
https://ntp.niehs.nih.gov/go/14433

Target Organs and Levels of Evidence for TR-355

Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Diphenhydramine hydrochloride
147-24-0
10/03/1988AntihistamineDosed-Feed
MR: 0, 313, OR 625 FR&M: 0, 156, OR 313 PPM; 50/GROUP
SRI International

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Brain: ASTROCYTOMA 0/49 0/49 3/50 OR GLIOMA 1/49 0/49 1/50 COMBINED 1/49 0/49 4/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/49 5/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 1/50 2/50 COMBINED 1/49 6/50 5/50
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pituitary Gland: ADENOMA 23/50 26/50 35/50
Male Mice: No Evidence
Female Mice: No Evidence