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Target Organs and Levels of Evidence for TR-356

Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Furosemide
54-31-9
04/18/1988Diuretic in the treatment of edema and hypertension. Diuretic in veterinary medicine. Dosed-Feed
R: 0,350,700, M: 0,700,1400 PPM/50 PER GROUP
SRI International

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 3/50 1/50 OR CARCINOMA 0/50 1/50 1/50 COMBINED 1/50 4/50 2/50
  • Brain: MENINGIOMA 0/50 3/50 0/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: ADENOCARCINOMA 0/50 2/50 5/48
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY