https://ntp.niehs.nih.gov/go/8911

Target Organs and Levels of Evidence for TR-357

Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Hydrochlorothiazide
58-93-5		 04/18/1988 Dosed-Feed
R: 0,250,500,2000 PPM/60 PER GROUP, M: 0,2500,5000 PPM/50 PER GROUP		 SRI International

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 3/48 8/49 14/50 OR CARCINOMA 4/48 4/49 9/50 COMBINED 7/48 10/49 21/50
Female Mice: No Evidence