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Target Organs and Levels of Evidence for TR-357

Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Hydrochlorothiazide
58-93-5
04/18/1988Diuretic for hypertension treatment and in veterinary medicine. Adjunct for treatment of edema. Dosed-Feed
R: 0,250,500,2000 PPM/60 PER GROUP, M: 0,2500,5000 PPM/50 PER GROUP
SRI International

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 3/48 8/49 14/50 OR CARCINOMA 4/48 4/49 9/50 COMBINED 7/48 10/49 21/50
Female Mice: No Evidence