National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8915

Target Organs and Levels of Evidence for TR-359

Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
8-Methoxypsoralen
298-81-7
04/18/1988Used in PUVA therapy for treatment of psoriasis & vitiligo, in tanning preparations (primarily production in Europe)Gavage
R: 0, 37.5, 75 MG/KG/50 PER GROUP
SRI International

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 11/50 8/49 OR ADENOCARCINOMA 0/50 1/50 3/49
  • Zymbal Gland: CARCINOMA 1/50 7/50 4/49
May Have Been Related
  • Subcutaneous Tissue: FIBROMA 1/50 5/50 7/49
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 9/50 9/49
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; PAPILLA, MINERALIZATION 0/50 0/50 31/49; HYPERPLASIA, TUBULAR CELL 0/50 8/50 8/49
  • FORESTOMACH: LESIONS
Female Rats: No Evidence


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