National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8919

Target Organs and Levels of Evidence for TR-361

Toxicology and Carcinogenesis Studies of Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Hexachloroethane
67-72-1
10/03/1988Solvent, in explosives, camphor substitute in celluloid, in production of metals, antihelmintic drug, moth repellant, rubber vulcanizing, flame proofing (HSDB 1990)Gavage
MR: 0, 10, 20, FR: 0, 80, 160 MG/KG/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 1/50
  • Kidney Tubular Cell: ADENOMA 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 7/50
May Have Been Related
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 15/50 28/45 21/49
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; MINERALIZATION 2/50 15/50 32/50; PELVIS, TRANSITIONAL EPITHELIUM, HYPERPLASIA 0/50 7/50 7/50
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; NEPHROPATHY 22/50 42/50 45/50


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