https://ntp.niehs.nih.gov/go/8929

Target Organs and Levels of Evidence for TR-366

Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Hydroquinone
123-31-9		 10/03/1988 Gavage
R: 0,25,50, M: 0,50,100 MG/KG/65 PER GROUP		 American Biogenics Corp (Bioassay Systems)

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: Adenoma 0/55 4/55 8/55
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: Leukemia 9/55 15/55 22/55
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Thyroid Gland: Follicular cell, hyperplasia
  • Liver: Anisokaryosis; basophilic focus; syncytial alteration
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55
Non-Neoplastic Lesions
  • Thyroid Gland: Follicular cell, hyperplasia