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Target Organs and Levels of Evidence for TR-375

Toxicology and Carcinogenesis Studies of Vinyl Toluene (Mixed Isomers) (65%-71% meta-isomer and 32%-35% para-isomer) (CASRN 25013-15-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Vinyl toluene
25013-15-4
11/20/1989Preparing polyester resins, modified alkyl resins, and drying oils. In orthopedic cast material.Inhalation
R: 0,100,300, M: 0,10,25 PPM/50 PER GROUP
Midwest Research Institute

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM, METAPLASIA
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM, METAPLASIA
Male Mice: No Evidence
Female Mice: No Evidence