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Target Organs and Levels of Evidence for TR-376

Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CASRN 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Allyl glycidyl ether
106-92-3
06/27/1989Stabilizer of chlorinated compounds, vinyl resins, rubber; resin intermediate.Inhalation
R&M: 0,5,10 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/44 0/46 1/43; ADENOCARCINOMA 0/44 0/46 1/43; SQUAMOUS CELL CARCINOMA 0/44 0/46 1/43
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 9/44 27/46 18/43; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/44 19/46 35/43; RESPIRATORY EPITHELIUM, HYPERPLASIA 4/44 33/46 30/43; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 4/44 40/46 38/43; OLFACTORY EPITHELIUM, DEGENERATION 0/44 45/46 43/43
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 5/49 7/48 11/47; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/48 31/47; RESPIRATORY EPITHELIUM, HYPERPLASIA 1/49 18/48 22/47; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 37/48 38/47; OLFACTORY EPITHELIUM, DEGENERATION 0/49 46/48 47/47
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 3/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 2/50 48/50 47/50; OLFACTORY EPITHELIUM, METAPLASIA 4/50 49/50 50/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/50 25/50 40/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/50 1/50 7/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/50 4/50 8/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/50 1/50 3/50
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/49 0/49 1/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 8/49 48/49 49/50; OLFACTORY EPITHELIUM, METAPLASIA 7/49 48/49 49/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/49 39/49 48/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/49 12/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/49 2/49 7/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/49 0/49 3/50