National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/12455

Target Organs and Levels of Evidence for TR-378

Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Benzaldehyde
100-52-7
06/27/1989Chemical intermediate for dyes. Solvent for oils, resins, some cellulose ethers, cellulose acetate and nitrate, flavoring compounds, synthetic perfumes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R&MM: 0, 200, OR 400 MG/KG FM: 0, 300, OR 600 MG/KG; 50/SEX/SPECIES
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 2/50 5/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA, FOCAL 7/50 8/50 16/50
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 5/50 6/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA 12/50 23/50 39/50


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.