https://ntp.niehs.nih.gov/go/12455

Target Organs and Levels of Evidence for TR-378

Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Benzaldehyde
100-52-7		 06/27/1989 Gavage
R&MM: 0, 200, OR 400 MG/KG FM: 0, 300, OR 600 MG/KG; 50/SEX/SPECIES		 Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 2/50 5/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA, FOCAL 7/50 8/50 16/50
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 5/50 6/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA 12/50 23/50 39/50