Target Organs and Levels of Evidence for TR-384
Toxicology and Carcinogenesis Studies of 1,2,3-Trichloropropane (CASRN 96-18-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
|---|
1,2,3-Trichloropropane
96-18-4 | 07/09/1991 | Paint and varnish remover. Solvent. Degreasing agent. Intermediate for polysulfide liquid polymers. | Gavage
R: 0,3,10,30, M: 0,6,20,60 MG/KG | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Oral Cavity:
SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52
- Forestomach:
SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52
- Pancreas Acinar Cell:
ADENOMA 5/50 21/50 36/49 29/52
- Kidney Tubular Cell:
ADENOMA 0/50 2/50 20/49 21/52
- Preputial Gland:
ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50
- Zymbal Gland:
CARCINOMA 0/60 0/60 0/59 3/60
|
| May Have Been Related | - Large Intestines:
ADENOCARCINOMA 0/50 0/50 2/48 1/52
|
| Non-Neoplastic Lesions | - FORESTOMACH: BASAL CELL AND SQUAMOUS HYPERPLASIA
- PANCREAS: ACINAR HYPERPLASIA
- KIDNEY: TUBULAR HYPERPLASIA; NEPHROPATHY
- PREPUTIAL GLAND:FOCAL HYPERPLASIA
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Oral Cavity:
SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52
- Forestomach:
SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52
- Clitoral Gland:
ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51
- Mammary Gland:
ADENOCARCINOMA 1/50 6/49 12/52 21/52
- Zymbal Gland:
CARCINOMA 0/60 1/59 0/60 4/60
|
| May Have Been Related | - Large Intestines:
ADENOCARCINOMA 0/49 0/47 1/52 2/52
|
| Non-Neoplastic Lesions | - FORESTOMACH: BASAL CELL AND SQUAMOUS HYPERPLASIA
- PANCREAS: ACINAR HYPERPLASIA
- KIDNEY: TUBULAR HYPERPLASIA; NEPHROPATHY
- CLITORAL GLAND: FOCAL HYPERPLASIA
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56
- Liver:
ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56
- Harderian Gland:
ADENOMA 1/52 2/51 10/54 11/56
|
| May Have Been Related | - Oral Cavity:
SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56
|
| Non-Neoplastic Lesions | - FORESTOMACH: SQUAMOUS HYPERPLASIA
- LIVER: EOSINOPHILIC FOCUS
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Oral Cavity:
SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55
- Forestomach:
SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55
- Liver:
ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55
- Harderian Gland:
ADENOMA 2/50 6/50 7/51 10/55
- Uterus/Cervix:
ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54
|
| Non-Neoplastic Lesions | - FORESTOMACH: SQUAMOUS HYPERPLASIA
- LIVER: EOSINOPHILIC FOCUS
|
