Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/9134

Target Organs and Levels of Evidence for TR-388

Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Ethylene thiourea (ETU)
96-45-7
04/25/1990Intermediate for antioxidants, insecticides, fungicides, dyes, pharmaceuticals. Accelerator for neoprene, epichlorohydrin, and polyethylene rubbers, degradation product of certain fungicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,25,83,250, M: 0,100,333,1000 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50
  • Liver: ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50
  • Pituitary Gland: ADENOMA 0/44 0/42 8/41
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
  • LIVER: CYTOMEGALY
  • PITUITARY GLAND: FOCAL HYPERPLASIA
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50
  • Liver: ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50
  • Pituitary Gland: ADENOMA 10/47 19/49 26/49; CARCINOMA 1/47 0/49 0/49
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
  • LIVER: CYTOMEGALY
  • PITUITARY GLAND: FOCAL HYPERPLASIA