National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9134

Target Organs and Levels of Evidence for TR-388

Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Ethylene thiourea (ETU)
96-45-7
04/25/1990Intermediate for antioxidants, insecticides, fungicides, dyes, pharmaceuticals. Accelerator for neoprene, epichlorohydrin, and polyethylene rubbers, degradation product of certain fungicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,25,83,250, M: 0,100,333,1000 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50
  • Liver: ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50
  • Pituitary Gland: ADENOMA 0/44 0/42 8/41
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
  • LIVER: CYTOMEGALY
  • PITUITARY GLAND: FOCAL HYPERPLASIA
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50
  • Liver: ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50
  • Pituitary Gland: ADENOMA 10/47 19/49 26/49; CARCINOMA 1/47 0/49 0/49
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
  • LIVER: CYTOMEGALY
  • PITUITARY GLAND: FOCAL HYPERPLASIA


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