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Target Organs and Levels of Evidence for TR-391

Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
tris(2-Chloroethyl) phosphate
115-96-8
04/25/1990Flame retardant. Plasticizer. Gavage
R: 0,44,88; M: 0,175,350 MG/KG/60 PER GROUP
BioReliance, Inc

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 5/50 24/50
May Have Been Related
  • Thyroid Gland Follicular Cell: ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50
Non-Neoplastic Lesions
  • KIDNEY: HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 2/50 5/50
May Have Been Related
  • Thyroid Gland Follicular Cell: ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50
Non-Neoplastic Lesions
  • KIDNEY: HYPERPLASIA
  • BRAIN: GLIOSIS; HEMORRHAGE; PIGMENTATION; MINERALIZATION
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 1/50 3/50
Non-Neoplastic Lesions
  • KIDNEY: KARYOMEGALY
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: ADENOMA 3/50 7/50 7/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 3/50 8/50 7/50
Non-Neoplastic Lesions
  • KIDNEY: KARYOMEGALY