National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9142

Target Organs and Levels of Evidence for TR-392

Toxicology and Carcinogenesis Studies of Chlorinated Water (CASRNs 7782-50-5 and 7681-52-9) and Chloraminated Water (CASRN 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chloraminated water
CHLORAMINEMX
11/19/1990Reagent, water disinfectantDosed-Water
R&M: 0,50,100,200 PPM/ 70 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 8/50 11/50 15/50 16/50
Male Mice: No Evidence
Female Mice: No Evidence


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chlorinated water
CHLORWATERMX
11/19/1990Chemicals used in the chlorination and chloramination of drinking water. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Water
R&M: 0,70,140,275 PPM/70 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 8/50 7/50 19/51 16/50
Male Mice: No Evidence
Female Mice: No Evidence


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