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Target Organs and Levels of Evidence for TR-393

Toxicology and Carcinogenesis Studies of Sodium Fluoride (CASRN 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking WaterStudies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Sodium fluoride
7681-49-4
04/26/1990Insecticide, enamels, glass mixes, steel de-gassing agent, electroplating fluxes, fluoridation of drinking water, disinfecting fermentation apparatus, preserving wood, pastes, manufacture coated paper, dental caries prophylactic (Merck 1989)Dosed-Water
R&M: 0,25,100,175 PPM
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Bone: OSTEOSARCOMA 0/80 0/50 1/50 3/80
Non-Neoplastic Lesions
  • TEETH: DENTINE, INCISOR, DYSPLASIA; INCISOR, AMELOBLAST, DEGENERATION; ATTRITION; DEFORMITY; DISCOLORATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • TEETH: DENTINE, INCISOR, DYSPLASIA; INCISOR, AMELOBLAST, DEGENERATION;ATTRITION; DEFORMITY; DISCOLORATION
  • BONE: OSTEOSCLEROSIS
Male Mice: No Evidence
Female Mice: No Evidence