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Target Organs and Levels of Evidence for TR-394

Toxicology and Carcinogenesis Studies of Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Acetaminophen (4-hydroxyacetanilide)
103-90-2
11/19/1990Manufacture of azo dyes, analgesic, intermediate for pharmaceuticals (HSDB 1990); derivative of p-aminophenol. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R&M:0,.06,.3,.6%/60 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY; TUBULAR HYPERPLASIA
  • PARATHYROID GLAND: HYPERPLASIA
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 9/50 17/50 15/50 24/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA