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Target Organs and Levels of Evidence for TR-396

Toxicology and Carcinogenesis Studies of Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Monochloroacetic acid
79-11-8
11/20/1990Chemical intermediate in the manufacture of various dyes and other organic materials. A postemergence contact herbicide.Gavage
R: 0,15,30; M: 0,50,100 MG/KG/70 & 60 PER GROUP RESPECTIVELY
International Research & Development Corp.

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: MUCOSA, INFLAMMATION
  • FORESTOMACH: SQUAMOUS HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: MUCOSA, INFLAMMATION; OLFACTORY EPITHELIUM, METAPLASIA
  • FORESTOMACH: SQUAMOUS HYPERPLASIA
Other Considerations
  • HEMATOPOIETIC SYSTEM: LYMPHOMA 29/60 18/60 13/60