National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10967

Target Organs and Levels of Evidence for TR-398

Toxicology and Carcinogenesis Studies of Polybrominated Biphenyls (Firemaster FF-1") (CASRN 67774-32-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Polybrominated biphenyl mixture (Firemaster FF-1)
67774-32-7
06/23/1992Major use as flame retardant for synthetic fibers & plasticsDosed-Feed
R & M: 0, 1, 3, 10, AND 30 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 10/49 38/50 OR CARCINOMA 0/50 2/49 19/50 COMBINED 1/50 12/49 41/50
Non-Neoplastic Lesions
  • LIVER: HYPERTROPHY; EOSINOPHILIC FOCUS; CYTOPLASMIC VACUOLIZATION; OVAL CELL HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 10/50 38/50 OR CARCINOMA 0/50 2/50 4/50 COMBINED 0/50 12/50 39/50
Non-Neoplastic Lesions
  • LIVER: HYPERTROPHY; EOSINOPHILIC FOCUS; CYTOPLASMIC VACUOLIZATION; OVAL CELL HYPERPLASIA
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 9/50 48/49 42/50; CARCINOMA 8/50 30/49 36/50
Non-Neoplastic Lesions
  • LIVER: CYTOMEGALY; FATTY CHANGE; BILE DUCT HYPERPLASIA
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 39/50 46/48; CARCINOMA 1/50 22/50 35/48
Non-Neoplastic Lesions
  • LIVER: CYTOMEGALY; FATTY CHANGE


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.