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Target Organs and Levels of Evidence for TR-408

Toxicology and Carcinogenesis Studies of Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Mercuric chloride
7487-94-7
07/10/1991Preserving wood. Embalming. Browning and etching steel and iron. Reagent. Chemical intermediate. Insecticide. Fungicide. Mordant for furs. Veterinary disinfectant and antiseptic. Gavage
R: 0,2.5,5, M: 0,5,10 MG/KG/60 PER GROUP
International Research & Development Corp.

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 3/50 12/50
May Have Been Related
  • Thyroid Gland Follicular Cell: ADENOMA 1/50 4/50 0/50 OR CARCINOMA 1/50 2/50 6/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY; TUBULAR HYPERPLASIA
  • FORESTOMACH: PAPILLARY HYPERPLASIA
  • NASAL CAVITY: INFLAMMATION
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/49 2/50
Non-Neoplastic Lesions
  • FORESTOMACH: PAPILLARY HYPERPLASIA
  • NASAL CAVITY: INFLAMMATION
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 2/49 OR ADENOCARCINOMA 0/50 0/50 1/49
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
  • NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
  • NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA