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Target Organs and Levels of Evidence for TR-409

Toxicology and Carcinogenesis Studies of Quercetin (CASRN 117-39-5) in F344 Rats (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Quercetin
117-39-5
03/12/1991 Capillary protectant (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Dosed-Feed
RATS ONLY:0,1000,10000,40000 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 3/50
    (SINGLE AND STEP SECTIONS) ADENOMA 1/50 2/50 7/50 8/50
    (SINGLE SECTIONS) ADENOCARCINOMA 0/50 0/50 0/50 1/50
    (SINGLE AND STEP SECTIONS) OVERALL ADENOMA OR ADENOCARCINOMA 1/50 2/50 7/50 9/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED INCIDENCE IN FOCAL HYPERPLASIA OF THE RENAL TUBULE EPITHELIUM
    KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
    PARATHYROID: INCREASED INCIDENCE OF HYPERPLASIA
Female Rats: No Evidence