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Target Organs and Levels of Evidence for TR-410

Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Naphthalene
91-20-3
03/11/1991Chemical intermediate, insecticides, repellants, antiseptic, vermicide, synthetic resins; in various commercial moth repellants and toilet bowl cleaners; topically in veterinary medicine. Prepared from coal tar. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,10 (75 mice/sex/group),30 (150 mice/sex/group) PPM
Man Tech, Inc.

Levels of Evidence

Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYPERPLASIA
  • LUNG: INFLAMMATION, CHRONIC
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 5/68 2/64 28/134
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, CHRONIC; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYPERPLASIA
  • LUNG: INFLAMMATION, CHRONIC