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Target Organs and Levels of Evidence for TR-414

Toxicology and Carcinogenesis Studies of Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pentachloroanisole
1825-21-4		11/21/1991Degradation product of other chemicals such as pentachlorophenol and pentachloronitrobenzeneGavage
MR: 0, 10, 20, OR 40 FR&M: 0, 20, OR 40 MG/KG		Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 12/50 17/50 23/50 15/48 OR MALIGNANT PHEOCHROMOCYTOMA 3/50 2/50 4/50 0/48 COMBINED 15/50 18/50 25/50 15/48
Non-Neoplastic Lesions
  • KIDNEY: PIGMENTATION, RENAL TUBULE EPITHELIUM
  • NASAL CAVITY: PIGMENTATION, OLFACTORY EPITHELIUM
  • LIVER: PIGMENTATION, HEPATOCYTES
  • PANCREAS: FOCAL HYPERPLASIA
Other Considerations
  • PANCREAS: 12/49 1/49 1/49 0/50
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 3/50 7/50 9/50
Non-Neoplastic Lesions
  • ADRENAL GLAND: HYPERPLASIA
  • KIDNEY: PIGMENTATION, RENAL TUBULE EPITHELIUM
  • NASAL CAVITY: PIGMENTATION, OLFACTORY EPITHELIUM
  • LIVER: PIGMENTATION, HEPATOCYTES
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA 19/50 10/50 7/50
  • UTERUS/CERVIX: STROMAL POLYP 13/50 13/50 7/50; STROMAL SARCOMA 2/50 1/50 0/50
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 0/50 4/50 7/48
  • Vascular System (Liver): HEMANGIOSARCOMA 2/50 8/50 10/50
Non-Neoplastic Lesions
  • ADRENAL GLAND: HYPERPLASIA; HYPERTROPHY
  • LIVER: CYTOLOGIC ALTERATION; KUPFFER CELL PIGMENTATION; BILIARY TRACT HYPERPLASIA; SUBACUTE INFLAMMATION; MIXED CELL FOCI
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CYTOLOGIC ALTERATION; KUPFFER CELL PIGMENTATION; BILIARY TRACT HYPERPLASIA; SUBACUTE INFLAMMATION