National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10485

Target Organs and Levels of Evidence for TR-418

Toxicology and Carcinogenesis Studies of p-Nitroaniline (CASRN 100-01-6) in B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p-Nitroaniline
100-01-6
11/21/1991Intermediate for antioxidants, dyes, pigments, gasoline gum inhibitors, veterinary medicine for poultry, pharmaceuticals (HSDB 1990)Gavage
0,3,30,100 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Liver): HEMANGIOSARCOMA 0/50 1/50 2/50 4/50
  • Vascular System (Unspecified): HEMANGIOMA 1/50 2/50 1/50 2/50 OR HEMANGIOSARCOMA 4/50 1/50 3/50 8/50 COMBINED 5/50 3/50 4/50 10/50
Female Mice: No Evidence


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