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Target Organs and Levels of Evidence for TR-419

Toxicology and Carcinogenesis Studies of HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
HC yellow 4
59820-43-8
07/09/1991In semi-permanent hair dye formulations (HSDB 1990).Dosed-Feed
MR: 0,0.25,0.5%, FR&M: 0,0.5,1.0%/70 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pituitary Gland: ADENOMA 17/45 20/49 28/49
Non-Neoplastic Lesions
  • PITUITARY GLAND: HYPERPLASIA
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA